(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyrazin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-methyloxazolidin-2-one

HRID 1804258

反応式

HRID 1804258 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[N:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:24])[CH:3]=1.[CH3:25][C@@H:26]1[CH2:30][O:29][C:28](=[O:31])[NH:27]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:27]4[C@H:26]([CH3:25])[CH2:30][O:29][C:28]4=[O:31])=[CH:3][C:4]=3[F:24])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[N:20]=1

参加物

3

反応物 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484696(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 58484514(R)-3-{4-[4-(3,5-dimethylpyrazin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-methyloxazolidin-2-one収率 82.2%

実験手順

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanone (611 mg) described in Preparation Example 105 and (R)-4-methyloxazolidin-2-one (212 mg) described in Preparation Example 25, the title compound (528 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 1
  2. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-d95294ffdef7408591894cb27f257f1a
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

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