2-Oxazolidinone → 3-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylpyridin-2-yl}-oxazolidin-2-one

HRID 1804328ノート

反応式

HRID 1804328 の反応式
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:26])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:19]=[N:20][C:21](F)=[C:22]([CH3:24])[CH:23]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[O:27]1[CH2:31][CH2:30][NH:29][C:28]1=[O:32]>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:26])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[C:22]([CH3:24])[C:21]([N:29]5[CH2:30][CH2:31][O:27][C:28]5=[O:32])=[N:20][CH:19]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 739492-OxazolidinoneHCID 58484721[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-5-methylpyridin-3-yl)methanone

生成物 1

HCID 584845943-{5-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylpyridin-2-yl}-oxazolidin-2-one収率 33.8%

実験手順

By reaction and treatment in the same manner as in Example 240 and using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-5-methylpyridin-3-yl)methanone (500 mg) described in Preparation Example 147 and oxazolidin-2-one (246 mg), the title compound (201 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 240

出典と根拠

ORDレコード
ord-c92297d886e5473183eab899bd4b13fe
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…