5,5-Dimethyloxazolin-2-one → 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one

HRID 1804337ノート

反応式

HRID 1804337 の反応式
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][C:29]1([CH3:35])[O:33][C:32](=[O:34])[N:31]=[CH:30]1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:31]5[CH2:30][C:29]([CH3:35])([CH3:28])[O:33][C:32]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 214647825,5-Dimethyloxazolin-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

生成物 1

HCID 584848433-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one収率 28.5%

実験手順

By reaction and treatment in the same manner as in Example 110 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95 and 5,5-dimethyloxazolin-2-one (138 mg) described in Preparation Example 43, the title compound (131 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 43

出典と根拠

ORDレコード
ord-62255c3df904408fa51cac6595620ee5
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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