5,5-Dimethyloxazolin-2-one → 3-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one

HRID 1804361ノート

反応式

HRID 1804361 の反応式
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[CH3:25][C:26]1([CH3:32])[O:30][C:29](=[O:31])[N:28]=[CH:27]1>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:28]4[CH2:27][C:26]([CH3:32])([CH3:25])[O:30][C:29]4=[O:31])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2]

参加物

3

反応物 2

HCID 214647825,5-Dimethyloxazolin-2-oneHCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

生成物 1

HCID 584846723-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one収率 51.2%

実験手順

By reaction and treatment in the same manner as in Example 110 and using [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (871 mg) described in Preparation Example 177 and 5,5-dimethyloxazolin-2-one (276 mg) described in Preparation Example 43, the title compound (433 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 43

出典と根拠

ORDレコード
ord-b83d1ba52fd94f329e6a44fb3ab64943
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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