(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(5-cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-4-methyloxazolidin-2-one

HRID 1804393ノート

反応式

HRID 1804393 の反応式
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[CH2:25][CH2:24]4)=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:26])[CH:3]=1.[CH3:27][C@@H:28]1[CH2:32][O:31][C:30](=[O:33])[NH:29]1>>[CH:23]1([C:20]2[CH:21]=[CH:22][C:17]([N:14]3[CH2:15][CH2:16][N:11]([C:9]([C:5]4[C:6]([F:8])=[CH:7][C:2]([N:29]5[C@H:28]([CH3:27])[CH2:32][O:31][C:30]5=[O:33])=[CH:3][C:4]=4[F:26])=[O:10])[CH2:12][CH2:13]3)=[N:18][CH:19]=2)[CH2:25][CH2:24]1

参加物

3

反応物 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

生成物 1

HCID 58484551(R)-3-{4-[4-(5-cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-4-methyloxazolidin-2-one収率 58.1%

実験手順

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone (422 mg) described in Preparation Example 189 and (R)-4-methyloxazolidin-2-one (134 mg) described in Preparation Example 25, the title compound (257 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-e7875cb73b3f4390acf124101819ec23
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

読み込み中…