Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoate → 3-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804407ノート

反応式

HRID 1804407 の反応式
[O:1]=[C:2]1[N:6]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1>>[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:6]4[CH2:5][CH2:4][O:3][C:2]4=[O:1])=[CH:17][CH:16]=3)=[O:13])[CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1

参加物

3

反応物 2

HCID 616604Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoateHCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazine

生成物 1

HCID 584848113-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one収率 15.8%

実験手順

By reaction and treatment in the same manner as in Example 34 and using ethyl 4-(2-oxooxazolidin-3-yl)benzoate (353 mg) described in Preparation Example 12 and 1-(2,6-dimethylpyridin-3-yl)piperazine (287 mg) described in Preparation Example 153, the title compound (90.2 mg) was obtained.

後処理

  1. customBy reaction and treatment in the same manner as in Example 34
  2. customdescribed in Preparation Example 153

出典と根拠

ORDレコード
ord-2f016fdd0c174f72b85a00e4faed29d4
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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