Hydrochloric Acid → [2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

HRID 1804569ノート

反応式

HRID 1804569 の反応式
[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[O:6][N:5]=1)([CH3:3])[CH3:2].[ClH:19]>ClCCl>[ClH:19].[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH2:11])[O:6][N:5]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric Acid2 回HCID 57637051Tert-butyl[2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate

生成物 1

HCID 46737067[2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

900 mg (3.53 mmol) tert-butyl [2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 10 ml dichloromethane, 20 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature. After the further addition of 10 ml ethereal hydrochloric acid the mixture is stirred for another 72 hours at ambient temperature and 4 hours at 40° C. The suspension is evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

後処理

  1. stirringis stirred for another 72 hours at ambient temperature and 4 hours at 40° C
  2. customThe suspension is evaporated down
  3. dissolutionThe residue is dissolved in acetone
  4. additionmixed with diethyl ether and suction
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-bfc0e7f40ba745ce897ed442f9458fe1
出典データセット
uspto-grants-2013_01
特許番号
US08354418B2

反応ノート

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