Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate → 4-(1,3-Thiazol-4-yl)piperidine
反応式
[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:3]=[CH:2]1>Cl.O1CCOCC1>[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:3]=[CH:2]1参加物
4
実験手順
The title compound from Step C above (280 mg, 1.04 mmol) was dissolved in 4 M HCl in dioxane (4.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-30) (237 mg, 94%). ESI-MS calculated for C8H12N2S: Exact Mass: 168.07. Found 169.07.
後処理
- concentrationThe product was concentrated under reduced pressure
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-bf3b05b113874f4195859adc25366651
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354403B2
反応ノート
読み込み中…