関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | N,N-Dimethylpiperidin-4-amine | HCID 417391 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine | HCID 11086151 | — |
反応手順
A 100 ml flask was charged with 1-fluoro-4-nitrobenzene (2.122 ml, 20 mmol), dimethylsulfoxide (30 ml), N,N-dimethylpiperidin-4-amine (2.82 g, 22.00 mmol) and triethylamine (5.58 ml, 40.0 mmol). The resulting solution was stirred at 100° C. under nitrogen for 24 hours. The reaction mixture was allowed to cool, and was poured in stirring cold water (1000 ml) and the solid collected by filtration and washed with water. The precipitate was vacuum dried to provide the title compound. MS (ESI(+)) m/e 249.9 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08354422B2 |
|---|
| 出典データセット | uspto-grants-2013_01 |
|---|
| ORD ID | ord-4067e18b2f174e3698967972cf5b3095 |
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| 出典メモ | uspto-grants-2013_01 |
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