Dimethyl Sulfoxide → N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

HRID 1804698

反応式

HRID 1804698 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.CS(C)=O.[CH3:15][N:16]([CH3:23])[CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C(N(CC)CC)C>O>[CH3:15][N:16]([CH3:23])[CH:17]1[CH2:22][CH2:21][N:20]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:19][CH2:18]1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 9590p-FluoronitrobenzeneHCID 417391N,N-Dimethylpiperidin-4-amine

生成物 1

HCID 11086151N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A 100 ml flask was charged with 1-fluoro-4-nitrobenzene (2.122 ml, 20 mmol), dimethylsulfoxide (30 ml), N,N-dimethylpiperidin-4-amine (2.82 g, 22.00 mmol) and triethylamine (5.58 ml, 40.0 mmol). The resulting solution was stirred at 100° C. under nitrogen for 24 hours. The reaction mixture was allowed to cool, and was poured in stirring cold water (1000 ml) and the solid collected by filtration and washed with water. The precipitate was vacuum dried to provide the title compound. MS (ESI(+)) m/e 249.9 (M+H)+.

後処理

  1. temperatureto cool
  2. additionwas poured
  3. filtrationthe solid collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-4067e18b2f174e3698967972cf5b3095
出典データセット
uspto-grants-2013_01
特許番号
US08354422B2

関連ノート

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