(-)-Dibenzoyltartrate → 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

HRID 1804761ノート

反応式

HRID 1804761 の反応式
[CH3:1][CH:2]1[CH:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[C:15]([C:23]([C:38]([O-:40])=[O:39])([OH:37])[C:24]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:28])[C:25]([O-:27])=[O:26])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(OCC)(=O)C>[C:29]([C:24]([C:25]([OH:27])=[O:26])([OH:28])[C:23]([C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([OH:37])[C:38]([OH:40])=[O:39])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1

参加物

4

反応物 2

HCID 21978704(-)-DibenzoyltartrateHCID 668421342,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester

生成物 1

HCID 1317301552,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester (5) (9.6 g, 48 mmol) is dissolved in 50 ml of ethyl acetate. A solution of (−)-dibenzoyltartrate (8.6 g, 24 mmol) in ethyl acetate is added drop wise. The precipitate is filtrated off and washed with cold ethyl acetate to yield colourless crystals.

後処理

  1. filtrationThe precipitate is filtrated off
  2. washwashed with cold ethyl acetate
  3. customto yield colourless crystals

出典と根拠

ORDレコード
ord-5dd345f6fc7e4ea281f841b92d6979a7
出典データセット
uspto-grants-2013_01
特許番号
US08354431B2

反応ノート

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