(3S,4S)-1-[2-(4-Amino-1-hydroxy-cyclohexyl)-ethyl]-3-methyl-piperidin-4-ol → 4-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

HRID 1804808ノート

反応式

HRID 1804808 の反応式
[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[CH:29]=[CH:28][C:10]2[C:11]([CH2:14][O:15][C:16]3[CH:24]=[CH:23][CH:22]=[C:21]4[C:17]=3[CH:18]=[C:19]([C:25](O)=[O:26])[NH:20]4)=[CH:12][O:13][C:9]=2[CH:8]=1)[CH3:2].[NH2:30][CH:31]1[CH2:36][CH2:35][C:34]([CH2:38][CH2:39][N:40]2[CH2:45][CH2:44][C@H:43]([OH:46])[C@@H:42]([CH3:47])[CH2:41]2)([OH:37])[CH2:33][CH2:32]1>>[OH:37][C:34]1([CH2:38][CH2:39][N:40]2[CH2:45][CH2:44][C@H:43]([OH:46])[C@@H:42]([CH3:47])[CH2:41]2)[CH2:35][CH2:36][CH:31]([NH:30][C:25]([C:19]2[NH:20][C:21]3[C:17]([CH:18]=2)=[C:16]([O:15][CH2:14][C:11]2[C:10]4[CH:28]=[CH:29][C:7]([O:6][CH2:5][CH2:4][O:3][CH2:1][CH3:2])=[CH:8][C:9]=4[O:13][CH:12]=2)[CH:24]=[CH:23][CH:22]=3)=[O:26])[CH2:32][CH2:33]1

参加物

3

反応物 2

HCID 59152645(3S,4S)-1-[2-(4-Amino-1-hydroxy-cyclohexyl)-ethyl]-3-methyl-piperidin-4-olHCID 591526774-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid

生成物 1

HCID 250058854-[6-(2-Ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid {4-hydroxy-4-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-cyclohexyl}-amide

実験手順

This compound is synthesized analogously to example 1 from 4-[6-(2-ethoxy-ethoxy)-benzofuran-3-ylmethoxy]-1H-indole-2-carboxylic acid 30c and amine 14.

出典と根拠

ORDレコード
ord-06e4441d48fa411cbb23d59defe2ae69
出典データセット
uspto-grants-2013_01
特許番号
US08354431B2

反応ノート

読み込み中…