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HRID 1805249作成日：2026年10月27日
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate
https://huagongshe.com/reaction/1805249
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate | HCID 3696469 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate | HCID 22831728 | — |
反応手順
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1128 mg) was dissolved in MeOH (23 ml) before addition of sodium methoxide (380 mg), the reaction mixture was stirred for 2 hours in a sealed tube at 110° C. The solvent was evaporated, the product dissolved in ethyl acetate and washed with water, the organics were dried over Na2SO4, and concentrated in vacuo to afford title compound as a colourless oil. MS (ISP) 237.0 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08354441B2 |
|---|
| 出典データセット | uspto-grants-2013_01 |
|---|
| ORD ID | ord-b44112ae04204f93bc669ab934edfad4 |
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| 出典メモ | uspto-grants-2013_01 |
|---|
