Acetone → 5-Fluoro-3-isopropylidene-1,3-dihydro-indol-2-one
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12][C:13]([CH3:15])=O.N1CCCCC1>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[C:13]([CH3:15])[CH3:12]参加物
5
実験手順
A mixture of 5-fluoro-1,3-dihydro-indol-2-one (2.84 g, 20 mmol), acetone (2.2 mL, 30 mmol) and piperidine (0.8 mL, 8 mmol) in methanol (100 mL) was heated to reflux for 16 hours. Then the reaction mixture was allowed to cool to room temperature. The solid was collected by filtration, washed with methanol (20 mL) and dried in vacuo to afford 5-fluoro-3-isopropylidene-1,3-dihydro-indol-2-one (2.6 g, 68%) as powder.
後処理
- temperaturewas heated
- temperatureto reflux for 16 hours
- filtrationThe solid was collected by filtration
- washwashed with methanol (20 mL)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-812991ae89c84fd390eb3e99cbf27e4b
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354443B2
反応ノート
読み込み中…