Chlorosuccinimide → 4-(4-(4-Acetyl-2,6-dimethylphenoxy)-7-chloro-5H-pyrrolo[3,2-d]pyrimidin-2-ylamino)benzonitrile
反応式
[C:1]([C:4]1[CH:28]=[C:27]([CH3:29])[C:7]([O:8][C:9]2[C:10]3[NH:26][CH:25]=[CH:24][C:11]=3[N:12]=[C:13]([NH:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)[N:14]=2)=[C:6]([CH3:30])[CH:5]=1)(=[O:3])[CH3:2].C1C(=O)N([Cl:38])C(=O)C1>C(Cl)Cl>[C:1]([C:4]1[CH:5]=[C:6]([CH3:30])[C:7]([O:8][C:9]2[C:10]3[NH:26][CH:25]=[C:24]([Cl:38])[C:11]=3[N:12]=[C:13]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=3)[N:14]=2)=[C:27]([CH3:29])[CH:28]=1)(=[O:3])[CH3:2]参加物
4
実験手順
To a solution of 4-(4-(4-acetyl-2,6-dimethylphenoxy)-5H-pyrrolo[3,2-d]pyrimidin-2-ylamino)benzonitrile (13 mg, 0.03 mmol) in CH2Cl2 (1 mL) was added NCS (4.4 mg, 0.03 mmol) and the mixture refluxed for 16 h. After the completion of the reaction, the solvent was concentrated and purified by preparative TLC eluting with hexanes:ethyl acetate (2:1) to give the product (4.2 mg, 30%).