Bromine → 5-(Benzyloxy)-3-bromopyridin-2-amine

HRID 1806091ノート

反応式

HRID 1806091 の反応式
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O-])(=O)C.[Na+].[Br:22]Br>C(O)(=O)C>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([Br:22])[C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 669951705-Benzyloxy-pyridin-2-ylamine hydrochloride

生成物 1

HCID 582090735-(Benzyloxy)-3-bromopyridin-2-amine収率 17%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5-(Benzyloxy)pyridin-2-amine hydrochloride (52.3 g, 221 mmol) and sodium acetate (45.3 g, 552 mmol) were dissolved in acetic acid (300 mL). Bromine (11.3 mL, 221 mmol) was added slowly and stirred at ambient temperature for 18 hours. After an aqueous workup, the material was purified over silica gel to give the title compound (10.5 g, 17.0% yield).

後処理

  1. customAfter an aqueous workup, the material was purified over silica gel

出典と根拠

ORDレコード
ord-6750e4ac7a1a448796288b9d4020c74f
出典データセット
uspto-grants-2013_01
特許番号
US08354540B2

反応ノート

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