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Ammonia → 4-Methyl-sulfonylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | 4-(Methylthio)pyridine | HCID 140938 | — |
| 反応物 | 4-Methanesulfonylpyridine | HCID 292487 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 触媒 | Sodium tungstate | HCID 26052 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Methyl-sulfonylpyridine | HCID 86598630 | — |
反応手順
4-Methylsulfonylpyridine may be prepared by carrying out the procedure as described in Example 20, starting with 14 g of sodium tungstate, 4 cm3 of water, 0.05 cm3 of 100% acetic acid, 3.3 g of 4-methylsulfanyl-pyridine, 6.5 cm3 of 30% hydrogen peroxide and then 0.25 cm3 of 32% aqueous ammonia and 1 cm3 of 37.5% aqueous solution of sodium hydrogen sulfite. The crude oil obtained is crystallized with 10 cm3 of diisopropyl ether, the crystals are filtered, drained and dried under reduced pressure (2.7 kPa). 2.6 g of 4-methyl-sulfonylpyridine are obtained in the form of white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741316B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0849b5bd46324f2ca8a266329f580a42 |
| 出典メモ | uspto-grants-2010_06 |