Dimethylamine → 5-[3-{[(2,2-dimethylpropyl)amino]methyl}-4,5-bis(methyloxy)phenyl]-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide
反応式
C[N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:16]=[C:17]3[C:21](=[C:22]([C:24]([NH2:26])=[O:25])[CH:23]=2)[NH:20][CH:19]=[C:18]3[CH:27]2[CH2:32][CH2:31][N:30]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])[CH2:29][CH2:28]2)[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH3:3].CNC>>[CH3:4][C:5]([CH3:6])([CH3:10])[CH2:3][NH:2][CH2:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:16]=[C:17]3[C:21](=[C:22]([C:24]([NH2:26])=[O:25])[CH:23]=2)[NH:20][CH:19]=[C:18]3[CH:27]2[CH2:28][CH2:29][N:30]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])[CH2:31][CH2:32]2)[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared according to the general procedure of 5-[3-[(dimethylamino)methyl]-4,5-bis(methyloxy)phenyl]-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide, substituting (2,2-dimethylpropyl)amine (20 μL, 0.30 mmol) for dimethylamine to afford 10 mg of the title compound (29.2%).