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HRID 1806544作成日：2026年10月26日

1-Propylethylenediamine → N-cyclopropyl-3-(8-(2,6-difluorophenyl)-7-oxo-2-{[2-(propylamino)ethyl]amino}-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)-4-methylbenzamide

https://huagongshe.com/reaction/1806544

反応式

関与物質

役割名称HCID仕込み量
反応物1-PropylethylenediamineHCID 66073—
反応物N-cyclopropyl-3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzamideHCID 57434545—
生成物N-cyclopropyl-3-(8-(2,6-difluorophenyl)-7-oxo-2-{[2-(propylamino)ethyl]amino}-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)-4-methylbenzamideHCID 11947934—

反応手順

The title compound is prepared from N-cyclopropyl-3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzamide and N-propyl-1,2-ethanediamine following the General Procedure for Sulfoxide/Sulfone Displacement, disclosed above. The concentrated reaction mixture is purified via reversed-phase HPLC. The desired product is obtained as a yellow solid (m.p. 120-134)>95% pure by HPLC (65 mg, 61%): LC-MS m/z 533 (M+H)+, 1.84 min (ret time).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08354416B2
出典データセットuspto-grants-2013_01
ORD IDord-efa6c87b1d0c43269dfce4241e0d65a3
出典メモuspto-grants-2013_01