Potassium Cyanide → 4-Chloro-2-methylbenzeneacetonitrile
反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[C:4]([CH3:10])[CH:3]=1.[C-:11]#[N:12].[K+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][C:11]#[N:12])=[C:4]([CH3:10])[CH:3]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
Step B To a solution of 4-chloro-2-methylbenzyl chloride (5.2 g, 30 mmol) in ethanol (40 mL) was added an aqueous solution (30 mL) of KCN (5 g, 77 mmol) at room temperature. The reaction mixture was then heated at 100° C. for 2 h. The mixture was cooled to room temperature and concentrated. The residue was partitioned between ethyl acetate and water. The organic layer was separated, concentrated. The residue was purified by chromatography (EtOAc:hexanes=1:10, then 1:4) to give 4-chloro-2-methylbenzyl cyanide as a yellow oil (3.5 g, 66%).
後処理
- temperatureThe mixture was cooled to room temperature
- concentrationconcentrated
- customThe residue was partitioned between ethyl acetate and water
- customThe organic layer was separated
- concentrationconcentrated
- customThe residue was purified by chromatography (EtOAc
出典と根拠
- ORDレコード
- ord-af47db2144e14e4083848c84f1b7a058
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354444B2
反応ノート
読み込み中…