化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Cyanide → 2-(4-Chloro-2-methoxyphenyl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 4-Chloro-1-(chloromethyl)-2-methoxybenzene | HCID 18523560 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(4-Chloro-2-methoxyphenyl)acetonitrile | HCID 22327524 | 36.7% |
反応手順
Step B In a manner similar to the method described in Example 57 Step B, 4-chloro-2-methoxybenzyl chloride (5.1 g, 27 mmol) was reacted with NaCN (3 g, 61 mmol) in ethanol (40 mL) and water (20 mL) at 100° C. for 8 h to give 4-chloro-2-methoxybenzyl cyanide as a colorless oil (1.8 g, 36%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08354444B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-63d99f0dddee4c84a99ab6a01ccd95eb |
| 出典メモ | uspto-grants-2013_01 |