Ethyl 3,3,4-trimethylpentanoate → 3,3,4-Trimethylpentan-1-ol

HRID 1806850ノート

反応式

HRID 1806850 の反応式
C([O:3][C:4](=O)[CH2:5][C:6]([CH3:11])([CH3:10])[CH:7]([CH3:9])[CH3:8])C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C(OCC)C>[CH3:10][C:6]([CH3:11])([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:4][OH:3]

参加物

4

反応物 2

HCID 10012374Ethyl 3,3,4-trimethylpentanoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 124253343,3,4-Trimethylpentan-1-ol収率 101.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
0 °C

実験手順

Step B To a solution of 3,3,4-trimethyl-pentanoic acid ethyl ester (7 g, 41 mmol) in anhydrous ethyl ether (100 mL) at 0° C. was added a ethyl ether solution (1 M) of LiAlH4 (67 mL, 67 mmol) under nitrogen. The reaction mixture was stirred at 0° C. for 1 h, then poured into a ice-water. The mixture was extracted with ethyl acetate. The organic layer were separated, washed with water, aqueous HCl solution, brine, dried over MgSO4, and concentrated to give 3,3,4-trimethyl-pentan-1-ol as a colorless oil (5.4 g, 100%).

後処理

  1. extractionThe mixture was extracted with ethyl acetate
  2. customThe organic layer were separated
  3. washwashed with water, aqueous HCl solution, brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-29866ab419074df19707c4844ffbc446
出典データセット
uspto-grants-2013_01
特許番号
US08354444B2

反応ノート

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