Water → 3-Ethyl-3-methyl-pentanoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:15])[CH:4]([C:9]([CH2:13][CH3:14])([CH3:12])[CH2:10][CH3:11])C(OC)=O.[Li+].[Cl-].O>CS(C)=O>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:9]([CH2:13][CH3:14])([CH3:12])[CH2:10][CH3:11]参加物
5
反応条件
- 温度
- 170 °C
実験手順
Step B To a solution of 2-(1-ethyl-1-methyl-propyl)-malonic acid dimethyl ester (3 g, 14 mmol) in DMSO (30 mL) was added LiCl (1.2 g, 28 mmol) and H2O (0.25 mL, 14 mmol). The reaction mixture was heated at 170° C. for 3 h, then poured into a ice-water, extracted with ethyl acetate. The organic layer were separated, washed with water, brine, dried over MgSO4, and concentrated to give 3-ethyl-3-methyl-pentanoic acid methyl ester as a yellow oil (1.5 g, 68%).
後処理
- extractionextracted with ethyl acetate
- customThe organic layer were separated
- washwashed with water, brine
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-d17603577ee94ee299d4a285500fba99
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354444B2
反応ノート
読み込み中…