Dichloromethane → HCID 178494953、化合物

反応式

[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].C([SiH2][O:15][C:16](C)(C)[C:17]([CH2:23]C)([CH2:21]C)[CH2:18][CH:19]=O)(C)(C)C.[CH2:27](Cl)Cl>>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:19]/[CH2:18][C:17]([CH3:23])([CH3:21])[CH2:16][O:15][CH3:27])([CH3:4])([CH3:3])[CH3:2]

参加物

反応物 3

HCID 6344Dichloromethane

HCID 151417Glycine tert-butyl ester

HCID 131730159HCID 131730159、化合物

生成物 1

HCID 178494953HCID 178494953、化合物収率 100%

実験手順

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.78 g, 5.8 mmol) was reacted with 3-(tert-butyl-dimethyl-silanyloxymethyl)-3-ethyl-pentanal (1.5 g, 5.8 mmol) in CH2Cl2 at room temperature for 18 h to give [4-methoxy-3,3-dimethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (2.2 g, 100%).

出典と根拠

ORDレコード: ord-7b9acf804d734ac38e952c252679d01f
出典データセット: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08354444B2

反応ノート

読み込み中…

参加物