Ethyl Acetate → 1-[2-methyl-2-((R)-1-oxiranylmethoxy)-propyl]-1H-pyrazol-3-ylamine

HRID 1807097ノート

反応式

HRID 1807097 の反応式
[CH3:1][C:2]([O:13][CH2:14][C@H:15]1[CH2:17][O:16]1)([CH3:12])[CH2:3][N:4]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[N:5]1.C(OCC)(=O)C.[H][H]>C(O)C>[CH3:12][C:2]([O:13][CH2:14][C@H:15]1[CH2:17][O:16]1)([CH3:1])[CH2:3][N:4]1[CH:8]=[CH:7][C:6]([NH2:9])=[N:5]1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 592496401-[2-methyl-2-((R)-1-oxiranylmethoxy)-propyl]-3-nitro-1H-pyrazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 592494671-[2-methyl-2-((R)-1-oxiranylmethoxy)-propyl]-1H-pyrazol-3-ylamine収率 103.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-[2-methyl-2-((R)-1-oxiranylmethoxy)-propyl]-3-nitro-1H-pyrazole (0.3 g, 1.24 mmol), and ethyl acetate (15 mL), ethanol (15 mL) was subjected to the H-Cube (Thales Nano) at 1 mL/min at 10° C., 10 psi hydrogen. The first time through not completely reduced. Resubjected and complete reduction of nitro group by NMR. Solvent was removed under reduced pressure to afford 1-[2-methyl-2-((R)-1-oxiranylmethoxy)-propyl]-1H-pyrazol-3ylamine as an oil (0.27 g, 100%).

後処理

  1. customwas subjected to the H-Cube (Thales Nano) at 1 mL/min at 10° C.
  2. customSolvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-9eb85ad0131646a0806f6873551df409
出典データセット
uspto-grants-2013_01
特許番号
US08354444B2

反応ノート

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