HCID 86644292、化合物 → HCID 25147517、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:28][P:29](=[O:36])([O:33]CC)[O:30]CC)[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18]([C:22]2[N:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:17][CH2:16]3)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>ClCCl.CO>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:28][P:29](=[O:30])([OH:33])[OH:36])[C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18]([C:22]2[N:23]=[CH:24][CH:25]=[CH:26][N:27]=2)[CH2:17][CH2:16]3)(=[O:10])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1参加物
4
実験手順
70 mg diethyl {[(3,5-dichloro-phenylsulphonyl)-(1-pyrimidin-2-yl-2,3-dihydro-1H-indol-5-yl)-amino]-methyl}-phosphonate are dissolved in 3 ml dichloromethane. Under argon 200 μl trimethylsilylbromide are added thereto and the mixture is refluxed for 2 hours. After cooling to ambient temperature 1 ml of methanol is added and the mixture is stirred for a further 1 hour. Then the solvents are eliminated in vacuo. The residue is taken up in 3 ml of methanol, stirred for 10 minutes and the solvent is eliminated in vacuo. The residue thus obtained is extracted from dichloromethane with 1% methanol. The solid is suction filtered and dried.