HCID 11356337、化合物 → N-(4-hydroxyphenyl)-2-methylsulfonylacetamide
反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:22])[CH2:17][S:18]([CH3:21])(=[O:20])=[O:19])=[CH:11][CH:10]=1)C1C=CC=CC=1.OC1C=CC(NC(C2C=CC=CN=2)=O)=CC=1>>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16](=[O:22])[CH2:17][S:18]([CH3:21])(=[O:20])=[O:19])=[CH:13][CH:14]=1参加物
3
実験手順
This compound was prepared from N-(4-benzyloxy-phenyl)-2-methanesulfonyl-acetamide, using the same method used to prepare of pyridine-2-carboxylic acid (4-hydroxyphenyl)amide. The product was purified by flash chromatography, on silica gel, eluted with 5 to 10% methanol in DCM, to give the product, 3.45 g (92%) as a colorless solid. MS m/z 230 (MH+). 1H NMR (DMSO-d6) δ 3.18 (s, 3H), 4.22 (s, 2H), 6.72 (d, 2H), 7.36 (d, 2H), 9.35 (br s, 1H) and 10.17 (s, 1H). Anal. calcd for C9H11N4OS: C, 47.15; H, 4.84; N, 6.11. Found: C, 47.04; H, 4.79; N, 6.04.
後処理
- customThe product was purified by flash chromatography, on silica gel
- washeluted with 5 to 10% methanol in DCM
- custom