Cyanogen Bromide → (S)-4-{2-[1-(4-chloro-phenyl)-cyclopropyl]-ethyl}-4,5-dihydro-oxazol-2-ylamine

反応式

[NH2:1][C@@H:2]([CH2:5][CH2:6][C:7]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)[CH2:3][OH:4].[N:17]#[C:18]Br>>[Cl:16][C:13]1[CH:12]=[CH:11][C:10]([C:7]2([CH2:6][CH2:5][C@H:2]3[CH2:3][O:4][C:18]([NH2:17])=[N:1]3)[CH2:9][CH2:8]2)=[CH:15][CH:14]=1

参加物

反応物 2

HCID 10476Cyanogen Bromide

HCID 67179178(S)-2-amino-4-[1-(4-chloro-phenyl)-cyclopropyl]-butan-1-ol

生成物 1

HCID 45101109(S)-4-{2-[1-(4-chloro-phenyl)-cyclopropyl]-ethyl}-4,5-dihydro-oxazol-2-ylamine

実験手順

In analogy to example 1d (S)-2-amino-4-[1-(4-chloro-phenyl)-cyclopropyl]-butan-1-ol was reacted with cyanogen bromide to give (S)-4-{2-[1-(4-chloro-phenyl)-cyclopropyl]-ethyl}-4,5-dihydro-oxazol-2-ylamine. White solid. MS (ISP): 265.1 ([M+H]+))

出典と根拠

ORDレコード: ord-dc9253263f0343829bf07504f1b7c284
出典データセット: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08357712B2

反応ノート

読み込み中…