Acetic Acid → Methyl 5-formyl-1H-imidazole-4-carboxylate
反応式
C(O)(=O)C.[CH2:5]([O:7][CH:8]([O:18]CC)[C:9]1[N:10]=[CH:11][NH:12][C:13]=1[C:14](OC)=[O:15])C.C1(C)C=CC=CC=1>O>[CH:14]([C:13]1[N:12]=[CH:11][NH:10][C:9]=1[C:8]([O:7][CH3:5])=[O:18])=[O:15]参加物
5
反応条件
- 温度
- 25 °C
実験手順
Acetic acid (244 mmol, 34.7 equiv.) was added to a solution of methyl 4-(diethoxy-methyl)-1H-imidazole-5-carboxylate (7.04 mmol, 1 equiv.) in water (4.2 ml), and the resulting mixture was stirred for 6 h at 25° C. under nitrogen. Toluene was added to the reaction mixture, and the solvent was removed in vacuo in order thus to yield the desired product in the form of a yellow solid. This was used in the following stage without further purification. Yield: quantitative
後処理
- customthe solvent was removed in vacuo in order thus
出典と根拠
- ORDレコード
- ord-2f46f2d9a1594ba69776bbf27ddf9117
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08357717B2
反応ノート
読み込み中…