Methyl cyanoacetate → Indole

HRID 1808672

反応式

HRID 1808672 の反応式
C[N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](C=O)=[C:3]1C1C=CC=CC=1.C(CC(OC)=O)#N.N1CCCCC1>CO>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

参加物

5

反応物 3

HCID 7747Methyl cyanoacetateHCID 8082PiperidineHCID 744681H-Indole-3-carboxaldehyde, 1-methyl-2-phenyl-

生成物 1

HCID 798Indole収率 263.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 120 ml of methanol were added 23.5 g (0.10 mol) of 1-methyl-2-phenyl-1H-indole-3-carbaldehyde and 11.9 g (0.12 mol) of methyl cyanoacetate to produce a mixture. Subsequently, 2.5 g (0.03 mol) of piperidine was added to the mixture, reacted under reflux for 6 hours, and cooled to room temperature to precipitate a crystal. The obtained crystal was washed with a small amount of methanol, and then dried to give 30.9 g of a light-yellow crystalline indole compound A having a structure of the general Chemical Formula (1) in which R1 was methyl group and R2 was methyl group. The melting point of the obtained indole compound A was 193.7° C.

後処理

  1. customto produce a mixture
  2. customreacted
  3. temperatureunder reflux for 6 hours
  4. customto precipitate a crystal
  5. washThe obtained crystal was washed with a small amount of methanol
  6. customdried

出典と根拠

ORDレコード
ord-49669eb5cbd143bb9afba59f582bd187
出典データセット
uspto-grants-2013_01
特許番号
US08361625B2

関連ノート

読み込み中…