Benzene → 1-Methyl-1-phenyl-ethylisocyanate

HRID 1808734

反応式

HRID 1808734 の反応式
C1C=CC=CC=1.[C:7]([NH2:16])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8].C(N(CC)CC)C.[C:24](Cl)(Cl)=[O:25]>C(OCC)C.C1(C)C=CC=CC=1>[N:16]([C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[C:24]=[O:25]

参加物

7

反応物 4

HCID 241BenzeneHCID 6371PhosgeneHCID 8471TriethylamineHCID 68509Cumylamine

生成物 1

HCID 27694301-Methyl-1-phenyl-ethylisocyanate

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
60 °C

実験手順

To a benzene (2 mL) solution of cumylamine (1.80 g, 13.3 mmol) and triethylamine (1.86 mL, 13.3 mmol) was added a 20% toluene solution of phosgene (17.5 mL, 33.3 mmol) dropwise. After completion, the reaction mixture was heated to 60° C. for 2 hours. It was then cooled to room temperature, charged with diethyl ether (20 mL), and filtered. Concentration of the filtrate in vacuo afforded the title compound. This crude product was used in the subsequent step without further purification.

後処理

  1. temperatureIt was then cooled to room temperature
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-fe3dccab2b714d998f38ddba15056b2c
出典データセット
uspto-grants-2013_01
特許番号
US08361994B2

関連ノート

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