2-Chloroquinazoline → (S)-2-(quinazolin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester

HRID 18088

反応式

HRID 18088 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[N:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[N:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 740542-ChloroquinazolineHCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate

生成物 1

HCID 86593672(S)-2-(quinazolin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester収率 55.2%

実験手順

The title compound (0.6 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.68 g) and 2-chloroquinazolin (0.53 g) according to the method of D30.

出典と根拠

ORDレコード
ord-19677e9145174c38bc11ef68fdf901a1
出典データセット
uspto-grants-2010_06
特許番号
US07741329B2

関連ノート

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