Hydrochloric Acid → N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

HRID 1808905ノート

反応式

HRID 1808905 の反応式
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:37]>ClCCl.C(OCC)C>[ClH:37].[N:11]1([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 668200074-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

生成物 1

HCID 46937291N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

0.64 g of 4-[5-(3-difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (1.213 mmol) were dissolved in 20 mL of dichloromethane and 1.82 mL of a 2N solution of hydrochloric acid in diethyl ether was added. After stirring at room temperature for 16 h, the solvents were evaporated, the residue redissolved in water, the aqueous phase washed with dichloromethane and then lyophilized to yield the title compound.

後処理

  1. customthe solvents were evaporated
  2. dissolutionthe residue redissolved in water
  3. washthe aqueous phase washed with dichloromethane

出典と根拠

ORDレコード
ord-827c3813bbcf40bd8e84e843c37974f0
出典データセット
uspto-grants-2013_01
特許番号
US08362010B2

反応ノート

読み込み中…