Hydrochloric Acid → 2-(5,6-Dimethyl-1,4-diazepan-1-yl)-6-fluoroquinazoline
反応式
Cl.[F:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([N:13]1[CH2:19][CH:18]([CH3:20])[CH:17]([CH3:21])[N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)[N:7]=[CH:6]2>C(OCC)(=O)C>[CH3:21][CH:17]1[CH:18]([CH3:20])[CH2:19][N:13]([C:8]2[N:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([F:2])[CH:4]=3)[N:9]=2)[CH2:14][CH2:15][NH:16]1参加物
4
実験手順
Hydrogen chloride gas was bubbled through a 0° C. solution of compound 1-10 (338 mg, 0.9 mmol) in ethyl acetate (5 mL) for 1 minute. The reaction was sealed and stirred for 40 minutes. Concentration in vacuo gave the titled compound as a white solid. Data for 1-11: LC/MS: m/z (M+CH3CN)=315.2 found; 315.3 calculated.
後処理
- customThe reaction was sealed
- concentrationConcentration in vacuo
出典と根拠
- ORDレコード
- ord-90025d558e41422a9c773ad9a2f4c69c
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362009B2
反応ノート
読み込み中…