Ammonium Chloride → 1-methyl-1H-imidazole-2-carboxamide
反応式
[NH4+:1].[Cl-].C([O:5][C:6]([C:8]1[N:9]([CH3:13])[CH:10]=[CH:11][N:12]=1)=O)C>[OH-].[NH4+]>[CH3:13][N:9]1[CH:10]=[CH:11][N:12]=[C:8]1[C:6]([NH2:1])=[O:5]参加物
4
反応条件
- 温度
- 100 °C
実験手順
NH4Cl (0.150 g, 2.8 mmol) is added to a solution of 1-methyl-1H-imidazole-2-carboxylic acid ethyl ester (15.5 g, 101 mmol) in ammonium hydroxide 35% (112 mL) and the reaction is stirred for 6 h at 100° C. in a sealed reaction flask. The reaction is cooled to 0° C. and the solid formed filtered and washed with ice water and ether to give 1-methyl-1H-imidazole-2-carboxylic acid amide as brown crystals (6.9 g, 55%).
後処理
- temperatureThe reaction is cooled to 0° C.
- customthe solid formed
- filtrationfiltered
- washwashed with ice water and ether
出典と根拠
- ORDレコード
- ord-1ef714ab29924cd9a926a132c9abbbd0
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362018B2
反応ノート
読み込み中…