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HRID 1809196作成日：2026年10月26日
Mafenide Hydrochloride → 4-[(3-Bromo-6-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide
https://huagongshe.com/reaction/1809196
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Mafenide Hydrochloride | HCID 67313 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Bromo-8-chloro-6-methyl-imidazo[1,2-a]pyrazine | HCID 58337100 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | 4-[(3-Bromo-6-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide | HCID 58337164 | 75% |
反応手順
To a solution of 3-bromo-8-chloro-6-methyl-imidazo[1,2-a]pyrazine (350 mg, 1.42 mmol) in iBuOH (3 mL) is added 4-aminomethyl-benzenesulfonamide hydrochloride (334 mg, 1.42 mmol) and DIPEA (0.49 mL, 2.82 mmol). The reaction is stirred at 108° C. for 16 h. After this time the solution is allowed to cool, resulting in a thick precipitate that is filtered and washed with diethyl ether to give 4-[(3-bromo-6-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide as a beige solid (420 mg, 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08362018B2 |
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| 出典データセット | uspto-grants-2013_01 |
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| ORD ID | ord-2e16b03effa64d279051b3834f338cb3 |
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| 出典メモ | uspto-grants-2013_01 |
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