Bromine → 1-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

HRID 1809551ノート

反応式

HRID 1809551 の反応式
[N:1]1([C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH3:8])[CH2:3][CH2:2]1.[Br:13]Br>CO>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH2:8][Br:13])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

参加物

4

反応物 2

HCID 24408BromineHCID 27772501,4-Diacetylpiperidine

生成物 1

HCID 772303261-(1-Acetylpiperidin-4-yl)-2-bromoethan-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a 1000 mL flask, 1,1′-(piperidine-1,4-diyl)diethanone (38.0 g, 225 mmol) was dissolved in methanol (700 mL) and bromine (12.1 mL, 236 mmol) was added. After agitating for 3 hours the solvent was removed in vacuo. The resulting solid was washed with ethyl acetate, then distributed between ethyl acetate and sodium carbonate. The organic phase was separated, washed with brine, dried and evaporated to give the title compound.

後処理

  1. customwas removed in vacuo
  2. washThe resulting solid was washed with ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with brine
  5. customdried
  6. customevaporated

出典と根拠

ORDレコード
ord-1b241b13d0d54244b9caf410ba9038c1
出典データセット
uspto-grants-2013_01
特許番号
US08362037B2

反応ノート

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