Potassium Carbonate → 1-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

HRID 1809580ノート

反応式

HRID 1809580 の反応式
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CCO>[O:19]([C:18]1[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=[C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[CH:17]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 866410891-Benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

生成物 1

HCID 866410901-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea収率 29.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (2.10 g, 4.58 mmol) and K2CO3 (3.16 g, 22.9 mmol) was refluxed in EtOH (50 mL) for 18 hours. The reaction was cooled to ambient temperature, filtered and concentrated. The residue was purified by silica gel to provide 1-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (0.484 g, 29.8% yield).

後処理

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe residue was purified by silica gel

出典と根拠

ORDレコード
ord-7350c94515b844f889bd51dcab7af746
出典データセット
uspto-grants-2013_01
特許番号
US08362037B2

反応ノート

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