関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrile | HCID 1473374 | — |
| 反応物 | Sodium Phenoxide Trihydrate | HCID 23681143 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Phenoxy-5-(trifluoromethyl)picolinonitrile | HCID 67485286 | 67.5% |
反応手順
3-Chloro-5-(trifluoromethyl)picolinonitrile (0.220 g, 1.07 mmol) was combined with sodium phenoxide trihydrate (0.272 g, 1.60 mmol) and DMF (5 mL). The resulting mixture was heated to 80° C. and agitated for one hour. The mixture was then cooled, diluted with ether and washed with 1M NaOH, water (3×), brine, dried and evaporated to give crude 3-phenoxy-5-(trifluoromethyl)picolinonitrile (0.190 g, 67.5% yield) as red oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08362037B2 |
|---|
| 出典データセット | uspto-grants-2013_01 |
|---|
| ORD ID | ord-cf45a6206dbd441bbbec73d4dd1a5671 |
|---|
| 出典メモ | uspto-grants-2013_01 |
|---|
