Sulfuric Acid → 3-Phenoxy-5-(trifluoromethyl)picolinamide

HRID 1809598

反応式

HRID 1809598 の反応式
[O:1]([C:8]1[C:9]([C:18]#[N:19])=[N:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)[OH:21].[OH-].[NH4+]>>[O:1]([C:8]1[C:9]([C:18]([NH2:19])=[O:21])=[N:10][CH:11]=[C:12]([C:14]([F:17])([F:15])[F:16])[CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 674852863-Phenoxy-5-(trifluoromethyl)picolinonitrile

生成物 1

HCID 674866453-Phenoxy-5-(trifluoromethyl)picolinamide収率 84.3%

実験手順

3-Phenoxy-5-(trifluoromethyl)picolinonitrile (0.190 g, 0.719 mmol) was combined with 2 ml of sulfuric acid and agitated for 3 hours. Ice was added to the mixture, and the solution was basified with ammonium hydroxide solution. The resulting slurry was filtered and solids washed with water and dried in the air to afford 3-phenoxy-5-(trifluoromethyl)picolinamide (0.171 g, 84.3% yield) as a white solid.

後処理

  1. additionIce was added to the mixture
  2. filtrationThe resulting slurry was filtered
  3. washsolids washed with water
  4. customdried in the air

出典と根拠

ORDレコード
ord-370172ece5634327b70de642dfe49b82
出典データセット
uspto-grants-2013_01
特許番号
US08362037B2

関連ノート

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