Hydrazine → HCID 178478326、化合物
反応式
Br[C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=O.[NH2:19][NH2:20]>>[Br:10][C:11]1[CH:12]=[C:13]([C:14]2[C:2]3[C:3](=[N:4][C:5]([Cl:8])=[N:6][CH:7]=3)[NH:20][N:19]=2)[CH:16]=[CH:17][CH:18]=1参加物
4
実験手順
Alternatively, for compounds of formula Ib where X and Y are CH, in accordance to Scheme 3 below, 5-bromo-2,4-dichloro-pyrimidine (1) is reacted with 3-bromo-benzaldehyde (4) by a Grignard reaction and the corresponding coupled alcohol is oxidized to the ketone. The ketone is reacted with hydrazine to give 3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine. The remaining chloro group can then be replaced by reacting with the appropriate amine and the bromide can be displacement with the required amine under Buckwald conditions to give compounds Ib of this invention.
出典と根拠
- ORDレコード
- ord-aef62ac29587452a9a6b8da7027f7210
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362023B2
反応ノート
読み込み中…