Hydrochloric Acid → HCID 178511334、化合物

HRID 1809762ノート

反応式

HRID 1809762 の反応式
C(OC(=O)[NH:7][CH2:8][CH:9]([C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[CH:36]=1)[NH:10][C:11]1[N:16]=[C:15]([C:17]2[C:25]3[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[N:23][CH:24]=3)[NH:19][N:18]=2)[CH:14]=[CH:13][N:12]=1)(C)(C)C.Cl>CCO>[Cl:41][C:37]1[CH:36]=[C:35]([CH:9]([NH:10][C:11]2[N:16]=[C:15]([C:17]3[C:25]4[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]5[CH2:30][CH2:31][O:32][CH2:33][CH2:34]5)=[N:23][CH:24]=4)[NH:19][N:18]=3)[CH:14]=[CH:13][N:12]=2)[CH2:8][NH2:7])[CH:40]=[CH:39][CH:38]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178453678HCID 178453678、化合物

生成物 1

HCID 178511334HCID 178511334、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(2-(3-Chloro-phenyl)-2-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester (100 mg, 0.17 mmol) was dissolved in EtOH (4 mL), then HCl (4 mL) was added. The reaction mixture was stirred at room temperature for 10 hours. The solvent was removed under reduced pressure to afford the crude product which was purified by prep-HPLC to afford 1-(3-chloro-phenyl)-N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-ethane-1,2-diamine; hydrochloride. (Yield 24 mg, 23.7%).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customto afford the crude product which
  3. customwas purified by prep-HPLC

出典と根拠

ORDレコード
ord-89dd80a6721d4ae7980456cd34654d6a
出典データセット
uspto-grants-2013_01
特許番号
US08362023B2

反応ノート

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