2-Chloronicotinonitrile → (S)-2-[(3Cyano-pyridin-2-ylamino)methyl]-piperidine-1-carboxylic acid tert butyl ester

HRID 18099

反応式

HRID 18099 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[C:22]([C:23]#[N:24])=[CH:21][CH:20]=[CH:19][N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[C:22]([C:23]#[N:24])=[CH:21][CH:20]=[CH:19][N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 810792-ChloronicotinonitrileHCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate

生成物 1

HCID 86593678(S)-2-[(3Cyano-pyridin-2-ylamino)methyl]-piperidine-1-carboxylic acid tert butyl ester収率 28.9%

実験手順

The title compound (0.66 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (1.55 g) and 2-chloro-3-cyanopyridine (1.0 g) according to the method of D28.

出典と根拠

ORDレコード
ord-30d177a5a9b14b29988f36392bd58c77
出典データセット
uspto-grants-2010_06
特許番号
US07741329B2

関連ノート

読み込み中…