2-(3-Bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester → 2-(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-2-methyl-propionic acid ethyl ester

HRID 1810365ノート

反応式

HRID 1810365 の反応式
[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10](Br)[CH:9]=1)([CH3:7])[CH3:6])[CH3:2].CC1(C)C(C)(C)OB([C:26]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:27]=2[CH:28]=[O:29])O1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:9]=[C:10]([C:26]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:27]=2[CH:28]=[O:29])[C:11]([O:14][CH3:15])=[CH:12][CH:13]=1)([CH3:7])[CH3:6])[CH3:2]

参加物

3

反応物 2

HCID 574588052-(3-Bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl esterHCID 866405342-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde

生成物 1

HCID 866511152-(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-2-methyl-propionic acid ethyl ester

実験手順

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 2-(3-bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester and 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzaldehyde.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-3de480845b9c4cd3bccd255486eb8d71
出典データセット
uspto-grants-2013_01
特許番号
US08362044B2

反応ノート

読み込み中…