Ethylamine → (2'-Ethylaminomethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

反応式

[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[CH:21]=O)[CH:8]=[CH:9][CH:10]=1.[CH2:24]([NH2:26])[CH3:25]>>[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][C:12]=2[CH2:21][NH:26][CH2:24][CH3:25])[CH:8]=[CH:9][CH:10]=1

参加物

反応物 2

HCID 6341Ethylamine

HCID 86633174HCID 86633174、化合物

生成物 1

HCID 66604353(2'-Ethylaminomethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

実験手順

Prepared according to the procedure described in Example 1, Step 5, using the following starting materials: (2′-formyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester and ethylamine (2M in THF).

後処理

customPrepared

出典と根拠

ORDレコード: ord-40dde0c9cd1d4323be02fa090a5949ef
出典データセット: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08362044B2

反応ノート

読み込み中…