Ethylamine → [2'-Ethylaminomethyl-6-methoxy-4'-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester

HRID 1810523ノート

反応式

HRID 1810523 の反応式
[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=3)=[CH:16][C:15]=2[CH:26]=O)[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[CH2:29]([NH2:31])[CH3:30]>>[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=3)=[CH:16][C:15]=2[CH2:26][NH:31][CH2:29][CH3:30])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

参加物

3

反応物 2

HCID 6341EthylamineHCID 58149152HCID 58149152、化合物

生成物 1

HCID 58148813[2'-Ethylaminomethyl-6-methoxy-4'-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester

実験手順

Prepared according to the procedure described in Example 33, Step 4, using the following starting materials: [2′-formyl-6-methoxy-4′-(1-methyl-1H-pyrazol-4-yl)-biphenyl-3-yl]-acetic acid ethyl ester and ethylamine (2M in THF).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-9fa838e8cccd48f6bab3cb84279a7f20
出典データセット
uspto-grants-2013_01
特許番号
US08362044B2

反応ノート

読み込み中…