ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Thiazolidinedione → 5-[1-(5-Benzyl-6-oxo-5,6-dihydrophenanthridin-2-yl)methylidene]thiazolidine-2,4-dione

HRID 1811451
ノート
印刷プレビュー

反応式

HRID 1811451 の反応式
[CH2:1]([N:8]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]2[CH:13]=[C:12]([CH:23]=O)[CH:11]=[CH:10][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:25]1[CH2:29][C:28](=[O:30])[NH:27][C:26]1=[O:31]>C1(C)C=CC=CC=1.C(O)(=O)C.N1CCCCC1>[CH2:1]([N:8]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]2[CH:13]=[C:12]([CH:23]=[C:29]3[S:25][C:26](=[O:31])[NH:27][C:28]3=[O:30])[CH:11]=[CH:10][C:9]1=2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 2

HCID 5437ThiazolidinedioneHCID 862337835-Benzyl-6-oxo-5,6-dihydrophenanthridine-2-carboxaldehyde

生成物 1

HCID 866139515-[1-(5-Benzyl-6-oxo-5,6-dihydrophenanthridin-2-yl)methylidene]thiazolidine-2,4-dione収率 80%

試薬・触媒・溶媒 3

HCID 176Acetic Acid触媒HCID 8082Piperidine触媒
HCID 1140
Toluene
溶媒

実験手順

592 mg of 5-benzyl-6-oxo-5,6-dihydrophenanthridine-2-carboxaldehyde and 221 mg of 2,4-thiazolidinedione were suspended in 10 ml of toluene. Two drops of acetic acid and two drops of piperidine were added to the suspension, followed by heating and refluxing overnight. The reaction liquid was cooled, and the solid thus obtained was collected by filtration. The collected solid was washed with toluene-diethyl ether, and dried, giving 620 mg (80% yield) of 5-[1-(5-benzyl-6-oxo-5,6-dihydrophenanthridin-2-yl)methylidene]thiazolidine-2,4-dione as a yellow solid.

後処理

  1. temperatureby heating
  2. temperaturerefluxing overnight
  3. customThe reaction liquid
  4. temperaturewas cooled
  5. customthe solid thus obtained
  6. filtrationwas collected by filtration
  7. washThe collected solid was washed with toluene-diethyl ether
  8. customdried

出典と根拠

ORDレコード
ord-2ff79f5966624f9b85db1e529c9f5692
出典データセット
uspto-grants-2013_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08362252B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート