Potassium Carbonate → Ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate

HRID 18117

反応式

HRID 18117 の反応式
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(C)=O>[C:21]1([CH2:20][CH2:19][CH2:18][N:1]2[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 12503(3-Bromopropyl)benzeneHCID 142179ethyl 1H-pyrazole-4-carboxylate

生成物 1

HCID 21958678Ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of ethyl 4-pyrazole carboxylate (3.57 mmol) in acetone (30 ml) was added potassium carbonate (35.7 mmol) and 1-bromo-3-phenylpropane (3.57 mmol). The suspension was refluxed overnight, after which the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water, the organic layer dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give an oil, which was purified by preparative TLC, to give ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate.

後処理

  1. temperatureThe suspension was refluxed overnight
  2. customafter which the solvent was removed under reduced pressure
  3. customThe residue was partitioned between ethyl acetate and water
  4. dry with materialthe organic layer dried over magnesium sulfate
  5. filtrationfiltered
  6. customthe filtrate evaporated under reduced pressure
  7. customto give an oil, which
  8. customwas purified by preparative TLC

出典と根拠

ORDレコード
ord-57a789f1727f4969851ec17937bcffa5
出典データセット
uspto-grants-2010_06
特許番号
US07741331B2

関連ノート

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