反応式
[F:1][C:2]1[C:7](B(O)O)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:12]1[N:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=[C:14]([NH2:22])[CH:13]=1>>[F:1][C:2]1[C:7]([C:12]2[N:17]=[C:16]([C:18]([F:20])([F:19])[F:21])[N:15]=[C:14]([NH2:22])[CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1参加物
3
実験手順
The title compound was prepared in an analogous manner to that described above in Example 4 using 2-fluoropyridin-3-ylboronic acid and 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (SynChem Inc., Elk Grove Village, Ill.), and the desired product 6-(2-fluoropyridin-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine was isolated as a white solid (34%). LCMS (API-ES) m/z 259 (M+H)+; 1H NMR (400 MHz, d6-DMSO) δ 8.57 (t, J=8.80 Hz, 1H) 8.38 (d, J=3.91 Hz, 1H) 7.83 (br. s., 2H) 7.46-7.63 (m, 1H) 7.15 (s, 1H).
後処理
- customThe title compound was prepared in an analogous manner to that
出典と根拠
- ORDレコード
- ord-c9d3d443a1e64b9c86012cbcd65f6cfa
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08362241B2
関連ノート
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