Sodium Dithionite → 5,6-diamino-1-benzylpyrimidine-2,4(1H,3H)-dione
反応式
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1[N:17]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>N>[NH2:17][C:3]1[C:4](=[O:16])[NH:5][C:6](=[O:15])[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:2]=1[NH2:1]参加物
4
実験手順
To a solution of 6-amino-5-nitroso-1-benzyl-1,3-dihydropyrimidine-2,4-dione (1.15 g, 4.7 mmol) in 12.5% aqueous ammonia (40 ml) at 70° C. was added sodium hydrosulfite (2.44 g, 14 mmol) in portions over 15 minutes. On cooling the reaction mixture in an ice bath the product precipitated out. It was filtered, washed with water, and dried under reduced pressure, to provide 5,6-diamino-1-benzyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (21).
後処理
- temperatureOn cooling the reaction mixture in an ice bath the product
- customprecipitated out
- filtrationIt was filtered
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-0bf579918d39490c951ea9dfbb1ba96e
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741331B2
反応ノート
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